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Can RTX 5080 run Qwen Qwen3 Next 80B A3b Thinking?

Qwen Qwen3 Next 80B A3b Thinking speed on RTX 5080 and quantization-level VRAM fit.

Q4 not recommended16GB VRAM availableRequires 40GB+

RTX 5080 does not meet the minimum VRAM requirement for Q4 inference of Qwen Qwen3 Next 80B A3b Thinking. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

Buy options for RTX 5080Best GPU guidesCompare prebuilt systems
Short answer: RTX 5080 is not a comfortable Q4 fit for Qwen Qwen3 Next 80B A3b Thinking (about 40GB needed).
Estimated speed
32 tok/s
VRAM needed
40GB
VRAM headroom
-24GB

What this means for you

RTX 5080 lacks sufficient VRAM for comfortable Qwen Qwen3 Next 80B A3b Thinking operation with Q4 quantization.

Your 16GB GPU is 24GB short of the 40GB minimum.

Options: (1) Try Q2 or Q3 quantization for lower VRAM requirements, (2) Consider cloud GPU rental, (3) Upgrade to a GPU with at least 16GB VRAM.

Quantization breakdown

QuantizationVRAM neededVRAM availableEstimated speedVerdict
Q440GB16GB31.62 tok/s❌ Not recommended
Q880GB16GB22.13 tok/s❌ Not recommended
FP16160GB16GB12.02 tok/s❌ Not recommended

Suitable alternatives

AMD Instinct MI300X
192GB
152.65 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Qwen Qwen3 Next 80B A3b Thinking on AMD Instinct MI300X
NVIDIA H200 SXM 141GB
141GB
137.85 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Qwen Qwen3 Next 80B A3b Thinking on NVIDIA H200 SXM 141GB
NVIDIA H100 SXM5 80GB
80GB
99.01 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Qwen Qwen3 Next 80B A3b Thinking on NVIDIA H100 SXM5 80GB
AMD Instinct MI250X
128GB
95.51 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Qwen Qwen3 Next 80B A3b Thinking on AMD Instinct MI250X
NVIDIA H100 PCIe 80GB
80GB
62.85 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Qwen Qwen3 Next 80B A3b Thinking on NVIDIA H100 PCIe 80GB

Compare purchase paths

Direct GPU buy options

Check current pricing links for RTX 5080 and similar cards.

Open RTX 5080 buy links →
Curated best GPU guides

Use workload-focused recommendations before committing to a purchase.

Browse best GPU guides →
Prebuilt AI systems

Compare complete systems if you want ready-to-run hardware.

Compare prebuilt systems →

More questions

RTX 5080 buy options & pricingFull guide for Qwen Qwen3 Next 80B A3b ThinkingBest GPU guides for this modelCompare prebuilt local AI systemsBrowse all model + GPU compatibility checksQwen Qwen3 Next 80B A3b Thinking Q4 requirementsQwen Qwen3 Next 80B A3b Thinking Q4_K_M requirementsCan AMD Instinct MI300X run Qwen Qwen3 Next 80B A3b Thinking?Can NVIDIA H200 SXM 141GB run Qwen Qwen3 Next 80B A3b Thinking?Can NVIDIA H100 SXM5 80GB run Qwen Qwen3 Next 80B A3b Thinking?

Compatibility FAQ

Can RTX 5080 run Qwen Qwen3 Next 80B A3b Thinking?

RTX 5080 is not a comfortable Q4 fit for Qwen Qwen3 Next 80B A3b Thinking (about 40GB needed).

How much VRAM is needed for Qwen Qwen3 Next 80B A3b Thinking on RTX 5080?

Q4 inference is estimated to need about 40GB VRAM on this page, while RTX 5080 has 16GB available.

What if RTX 5080 is not enough for Qwen Qwen3 Next 80B A3b Thinking?

Try lower-bit quantization, choose a smaller model, or move to a higher-VRAM GPU from the alternatives list.