AMD Instinct MI300X meets the minimum VRAM requirement for Q4 inference of Qwen/Qwen3-Next-80B-A3B-Thinking. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.
AMD Instinct MI300X can run Qwen/Qwen3-Next-80B-A3B-Thinking with Q4 quantization. At approximately 155 tokens/second, you can expect Excellent speed - conversational response times under 1 second.
You have 153GB headroom, which is sufficient for system overhead and smooth operation.
| Quantization | VRAM needed | VRAM available | Estimated speed | Verdict |
|---|---|---|---|---|
| Q4 | 39GB | 192GB | 154.62 tok/s | ✅ Fits comfortably |
| Q8 | 78GB | 192GB | 110.93 tok/s | ✅ Fits comfortably |
| FP16 | 156GB | 192GB | 52.86 tok/s | ✅ Fits comfortably |