Mistralai Mixtral 8x22b Instruct V0 1 speed on RTX 5080 and quantization-level VRAM fit.
RTX 5080 meets the minimum VRAM requirement for Q4 inference of Mistralai Mixtral 8x22b Instruct V0 1. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.
RTX 5080 can run Mistralai Mixtral 8x22b Instruct V0 1 with Q4 quantization. At approximately 113 tokens/second, you can expect Excellent speed - conversational response times under 1 second.
You have 5GB headroom, which is sufficient for system overhead and smooth operation.
| Quantization | VRAM needed | VRAM available | Estimated speed | Verdict |
|---|---|---|---|---|
| Q4 | 11GB | 16GB | 113.04 tok/s | ✅ Fits comfortably |
| Q8 | 22GB | 16GB | 79.13 tok/s | ❌ Not recommended |
| FP16 | 44GB | 16GB | 42.96 tok/s | ❌ Not recommended |
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Compare prebuilt systems →RTX 5080 can run Mistralai Mixtral 8x22b Instruct V0 1 at Q4 with an estimated 113 tok/s.
Q4 inference is estimated to need about 11GB VRAM on this page, while RTX 5080 has 16GB available.
If you need more speed or context headroom, compare alternative GPUs below and check higher-tier VRAM options.