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Can NVIDIA H200 SXM 141GB run Mistralai Mixtral 8x22b Instruct V0 1?

Mistralai Mixtral 8x22b Instruct V0 1 speed on NVIDIA H200 SXM 141GB and quantization-level VRAM fit.

Runs Q4141GB VRAM availableRequires 71GB+

NVIDIA H200 SXM 141GB meets the minimum VRAM requirement for Q4 inference of Mistralai Mixtral 8x22b Instruct V0 1. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

Buy options for NVIDIA H200 SXM 141GBBest GPU guidesCompare prebuilt systems
Short answer: NVIDIA H200 SXM 141GB can run Mistralai Mixtral 8x22b Instruct V0 1 at Q4 with an estimated 179 tok/s.
Estimated speed
179 tok/s
VRAM needed
71GB
VRAM headroom
+70GB

What this means for you

NVIDIA H200 SXM 141GB can run Mistralai Mixtral 8x22b Instruct V0 1 with Q4 quantization. At approximately 179 tokens/second, you can expect Excellent speed - conversational response times under 1 second.

You have 70GB headroom, which is sufficient for system overhead and smooth operation.

Quantization breakdown

QuantizationVRAM neededVRAM availableEstimated speedVerdict
Q471GB141GB179.21 tok/s✅ Fits comfortably
Q8141GB141GB125.45 tok/s⚠️ Tight fit
FP16282GB141GB68.10 tok/s❌ Not recommended

Suitable alternatives

AMD Instinct MI300X
192GB
198.45 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Mistralai Mixtral 8x22b Instruct V0 1 on AMD Instinct MI300X
NVIDIA H100 SXM5 80GB
80GB
128.72 tok/s
Price: —
Fit note: compare VRAM and speed with your target workload before buying.
Check Mistralai Mixtral 8x22b Instruct V0 1 on NVIDIA H100 SXM5 80GB
AMD Instinct MI250X
128GB
124.16 tok/s
Price: —
Fit note: compare VRAM and speed with your target workload before buying.
Check Mistralai Mixtral 8x22b Instruct V0 1 on AMD Instinct MI250X
NVIDIA H100 PCIe 80GB
80GB
81.71 tok/s
Price: —
Fit note: compare VRAM and speed with your target workload before buying.
Check Mistralai Mixtral 8x22b Instruct V0 1 on NVIDIA H100 PCIe 80GB
NVIDIA A100 80GB SXM4
80GB
75.94 tok/s
Price: —
Fit note: compare VRAM and speed with your target workload before buying.
Check Mistralai Mixtral 8x22b Instruct V0 1 on NVIDIA A100 80GB SXM4

GPU buying guides

Need a GPU with 71GB+ VRAM? These guides match your requirements.

Best GPU for 70B Models
High-VRAM options for the largest open models.
Read guide →
Best GPU for Deep Learning
Professional GPUs for training and inference at scale.
Read guide →

Compare purchase paths

Direct GPU buy options

Check current pricing links for NVIDIA H200 SXM 141GB and similar cards.

Open NVIDIA H200 SXM 141GB buy links →
Curated best GPU guides

Use workload-focused recommendations before committing to a purchase.

Browse best GPU guides →
Prebuilt AI systems

Compare complete systems if you want ready-to-run hardware.

Compare prebuilt systems →

Try before you buy

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Vast.aiFrom $0.20/hr · Pay as you goRent GPU →RunPodFrom $0.30/hr · Secure cloudRent GPU →Lambda LabsFrom $0.50/hr · Enterprise-gradeRent GPU →

More questions

NVIDIA H200 SXM 141GB buy options & pricingFull guide for Mistralai Mixtral 8x22b Instruct V0 1Best GPU guides for this modelCompare prebuilt local AI systemsBrowse all model + GPU compatibility checksMistralai Mixtral 8x22b Instruct V0 1 Q4 requirementsMistralai Mixtral 8x22b Instruct V0 1 Q4_K_M requirementsCan AMD Instinct MI300X run Mistralai Mixtral 8x22b Instruct V0 1?Can NVIDIA H100 SXM5 80GB run Mistralai Mixtral 8x22b Instruct V0 1?Can AMD Instinct MI250X run Mistralai Mixtral 8x22b Instruct V0 1?

Compatibility FAQ

Can NVIDIA H200 SXM 141GB run Mistralai Mixtral 8x22b Instruct V0 1?

NVIDIA H200 SXM 141GB can run Mistralai Mixtral 8x22b Instruct V0 1 at Q4 with an estimated 179 tok/s.

How much VRAM is needed for Mistralai Mixtral 8x22b Instruct V0 1 on NVIDIA H200 SXM 141GB?

Q4 inference is estimated to need about 71GB VRAM on this page, while NVIDIA H200 SXM 141GB has 141GB available.

What if NVIDIA H200 SXM 141GB is not enough for Mistralai Mixtral 8x22b Instruct V0 1?

If you need more speed or context headroom, compare alternative GPUs below and check higher-tier VRAM options.