Mistralai Mixtral 8x22b Instruct V0 1 speed on AMD Instinct MI250X and quantization-level VRAM fit.
AMD Instinct MI250X meets the minimum VRAM requirement for Q4 inference of Mistralai Mixtral 8x22b Instruct V0 1. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.
AMD Instinct MI250X can run Mistralai Mixtral 8x22b Instruct V0 1 with Q4 quantization. At approximately 124 tokens/second, you can expect Excellent speed - conversational response times under 1 second.
You have 57GB headroom, which is sufficient for system overhead and smooth operation.
| Quantization | VRAM needed | VRAM available | Estimated speed | Verdict |
|---|---|---|---|---|
| Q4 | 71GB | 128GB | 124.16 tok/s | ✅ Fits comfortably |
| Q8 | 141GB | 128GB | 86.92 tok/s | ❌ Not recommended |
| FP16 | 282GB | 128GB | 47.18 tok/s | ❌ Not recommended |
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AMD Instinct MI250X can run Mistralai Mixtral 8x22b Instruct V0 1 at Q4 with an estimated 124 tok/s.
Q4 inference is estimated to need about 71GB VRAM on this page, while AMD Instinct MI250X has 128GB available.
If you need more speed or context headroom, compare alternative GPUs below and check higher-tier VRAM options.