AMD Instinct MI250X meets the minimum VRAM requirement for Q4 inference of mistralai/Mixtral-8x22B-Instruct-v0.1. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.
AMD Instinct MI250X can run mistralai/Mixtral-8x22B-Instruct-v0.1 with Q4 quantization. At approximately 123 tokens/second, you can expect Excellent speed - conversational response times under 1 second.
You have 59GB headroom, which is sufficient for system overhead and smooth operation.
| Quantization | VRAM needed | VRAM available | Estimated speed | Verdict |
|---|---|---|---|---|
| Q4 | 69GB | 128GB | 122.62 tok/s | ✅ Fits comfortably |
| Q8 | 138GB | 128GB | 86.71 tok/s | ❌ Not recommended |
| FP16 | 275GB | 128GB | 48.64 tok/s | ❌ Not recommended |