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Can NVIDIA L40S run Mistralai Mixtral 8x22b Instruct V0 1?

Mistralai Mixtral 8x22b Instruct V0 1 speed on NVIDIA L40S and quantization-level VRAM fit.

Q4 not recommended48GB VRAM availableRequires 71GB+

NVIDIA L40S does not meet the minimum VRAM requirement for Q4 inference of Mistralai Mixtral 8x22b Instruct V0 1. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

Buy options for NVIDIA L40SBest GPU guidesCompare prebuilt systems
Short answer: NVIDIA L40S is not a comfortable Q4 fit for Mistralai Mixtral 8x22b Instruct V0 1 (about 71GB needed).
Estimated speed
43 tok/s
VRAM needed
71GB
VRAM headroom
-23GB

What this means for you

NVIDIA L40S lacks sufficient VRAM for comfortable Mistralai Mixtral 8x22b Instruct V0 1 operation with Q4 quantization.

Your 48GB GPU is 23GB short of the 71GB minimum.

Options: (1) Try Q2 or Q3 quantization for lower VRAM requirements, (2) Consider cloud GPU rental, (3) Upgrade to a GPU with at least 16GB VRAM.

Quantization breakdown

QuantizationVRAM neededVRAM availableEstimated speedVerdict
Q471GB48GB43.07 tok/s❌ Not recommended
Q8141GB48GB30.15 tok/s❌ Not recommended
FP16282GB48GB16.36 tok/s❌ Not recommended

Suitable alternatives

AMD Instinct MI300X
192GB
198.45 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Mistralai Mixtral 8x22b Instruct V0 1 on AMD Instinct MI300X
NVIDIA H200 SXM 141GB
141GB
179.21 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Mistralai Mixtral 8x22b Instruct V0 1 on NVIDIA H200 SXM 141GB
NVIDIA H100 SXM5 80GB
80GB
128.72 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Mistralai Mixtral 8x22b Instruct V0 1 on NVIDIA H100 SXM5 80GB
AMD Instinct MI250X
128GB
124.16 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Mistralai Mixtral 8x22b Instruct V0 1 on AMD Instinct MI250X
NVIDIA H100 PCIe 80GB
80GB
81.71 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Mistralai Mixtral 8x22b Instruct V0 1 on NVIDIA H100 PCIe 80GB
Need more VRAM for Mistralai Mixtral 8x22b Instruct V0 1?
NVIDIA L40S is 23GB short. Consider a GPU with 93GB+ VRAM.
Best GPU for 70B Models →Best GPU for Deep Learning →All buying guides →

Compare purchase paths

Direct GPU buy options

Check current pricing links for NVIDIA L40S and similar cards.

Open NVIDIA L40S buy links →
Curated best GPU guides

Use workload-focused recommendations before committing to a purchase.

Browse best GPU guides →
Prebuilt AI systems

Compare complete systems if you want ready-to-run hardware.

Compare prebuilt systems →

Not ready to upgrade?

Your GPU doesn't meet the VRAM requirements. Run Mistralai Mixtral 8x22b Instruct V0 1 on cloud GPU instantly.

Vast.aiFrom $0.20/hr · Pay as you goRent GPU →RunPodFrom $0.30/hr · Secure cloudRent GPU →Lambda LabsFrom $0.50/hr · Enterprise-gradeRent GPU →

More questions

NVIDIA L40S buy options & pricingFull guide for Mistralai Mixtral 8x22b Instruct V0 1Best GPU guides for this modelCompare prebuilt local AI systemsBrowse all model + GPU compatibility checksMistralai Mixtral 8x22b Instruct V0 1 Q4 requirementsMistralai Mixtral 8x22b Instruct V0 1 Q4_K_M requirementsCan AMD Instinct MI300X run Mistralai Mixtral 8x22b Instruct V0 1?Can NVIDIA H200 SXM 141GB run Mistralai Mixtral 8x22b Instruct V0 1?Can NVIDIA H100 SXM5 80GB run Mistralai Mixtral 8x22b Instruct V0 1?

Compatibility FAQ

Can NVIDIA L40S run Mistralai Mixtral 8x22b Instruct V0 1?

NVIDIA L40S is not a comfortable Q4 fit for Mistralai Mixtral 8x22b Instruct V0 1 (about 71GB needed).

How much VRAM is needed for Mistralai Mixtral 8x22b Instruct V0 1 on NVIDIA L40S?

Q4 inference is estimated to need about 71GB VRAM on this page, while NVIDIA L40S has 48GB available.

What if NVIDIA L40S is not enough for Mistralai Mixtral 8x22b Instruct V0 1?

Try lower-bit quantization, choose a smaller model, or move to a higher-VRAM GPU from the alternatives list.