Qwen Qwen2.5 72B Instruct speed on AMD Ryzen AI Max Pro 385 and quantization-level VRAM fit.
AMD Ryzen AI Max Pro 385 meets the minimum VRAM requirement for Q4 inference of Qwen Qwen2.5 72B Instruct. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.
AMD Ryzen AI Max Pro 385 can run Qwen Qwen2.5 72B Instruct with Q4 quantization. At approximately 7 tokens/second, you can expect Low speed - consider quantization or stronger GPU.
You have 92GB headroom, which is sufficient for system overhead and smooth operation.
| Quantization | VRAM needed | VRAM available | Estimated speed | Verdict |
|---|---|---|---|---|
| Q4 | 36GB | 128GB | 7.30 tok/s | ✅ Fits comfortably |
| Q8 | 72GB | 128GB | 5.11 tok/s | ✅ Fits comfortably |
| FP16 | 144GB | 128GB | 2.77 tok/s | ❌ Not recommended |
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AMD Ryzen AI Max Pro 385 can run Qwen Qwen2.5 72B Instruct at Q4 with an estimated 7 tok/s.
Q4 inference is estimated to need about 36GB VRAM on this page, while AMD Ryzen AI Max Pro 385 has 128GB available.
If you need more speed or context headroom, compare alternative GPUs below and check higher-tier VRAM options.