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Can RTX 5080 run Mistralai Mistral Small Instruct 2409?

Mistralai Mistral Small Instruct 2409 speed on RTX 5080 and quantization-level VRAM fit.

Q4 not recommended16GB VRAM availableRequires 20GB+

RTX 5080 does not meet the minimum VRAM requirement for Q4 inference of Mistralai Mistral Small Instruct 2409. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

Buy options for RTX 5080Best GPU guidesCompare prebuilt systems
Short answer: RTX 5080 is not a comfortable Q4 fit for Mistralai Mistral Small Instruct 2409 (about 20GB needed).
Estimated speed
55 tok/s
VRAM needed
20GB
VRAM headroom
-4GB

What this means for you

RTX 5080 lacks sufficient VRAM for comfortable Mistralai Mistral Small Instruct 2409 operation with Q4 quantization.

Your 16GB GPU is 4GB short of the 20GB minimum.

Options: (1) Try Q2 or Q3 quantization for lower VRAM requirements, (2) Consider cloud GPU rental, (3) Upgrade to a GPU with at least 16GB VRAM.

Quantization breakdown

QuantizationVRAM neededVRAM availableEstimated speedVerdict
Q420GB16GB55.34 tok/s❌ Not recommended
Q840GB16GB38.74 tok/s❌ Not recommended
FP1680GB16GB21.03 tok/s❌ Not recommended

Suitable alternatives

AMD Instinct MI300X
192GB
267.14 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Mistralai Mistral Small Instruct 2409 on AMD Instinct MI300X
NVIDIA H200 SXM 141GB
141GB
241.24 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Mistralai Mistral Small Instruct 2409 on NVIDIA H200 SXM 141GB
NVIDIA H100 SXM5 80GB
80GB
173.27 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Mistralai Mistral Small Instruct 2409 on NVIDIA H100 SXM5 80GB
AMD Instinct MI250X
128GB
167.14 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Mistralai Mistral Small Instruct 2409 on AMD Instinct MI250X
NVIDIA H100 PCIe 80GB
80GB
109.99 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Mistralai Mistral Small Instruct 2409 on NVIDIA H100 PCIe 80GB

Compare purchase paths

Direct GPU buy options

Check current pricing links for RTX 5080 and similar cards.

Open RTX 5080 buy links →
Curated best GPU guides

Use workload-focused recommendations before committing to a purchase.

Browse best GPU guides →
Prebuilt AI systems

Compare complete systems if you want ready-to-run hardware.

Compare prebuilt systems →

More questions

RTX 5080 buy options & pricingFull guide for Mistralai Mistral Small Instruct 2409Best GPU guides for this modelCompare prebuilt local AI systemsBrowse all model + GPU compatibility checksMistralai Mistral Small Instruct 2409 Q4 requirementsMistralai Mistral Small Instruct 2409 Q4_K_M requirementsCan AMD Instinct MI300X run Mistralai Mistral Small Instruct 2409?Can NVIDIA H200 SXM 141GB run Mistralai Mistral Small Instruct 2409?Can NVIDIA H100 SXM5 80GB run Mistralai Mistral Small Instruct 2409?

Compatibility FAQ

Can RTX 5080 run Mistralai Mistral Small Instruct 2409?

RTX 5080 is not a comfortable Q4 fit for Mistralai Mistral Small Instruct 2409 (about 20GB needed).

How much VRAM is needed for Mistralai Mistral Small Instruct 2409 on RTX 5080?

Q4 inference is estimated to need about 20GB VRAM on this page, while RTX 5080 has 16GB available.

What if RTX 5080 is not enough for Mistralai Mistral Small Instruct 2409?

Try lower-bit quantization, choose a smaller model, or move to a higher-VRAM GPU from the alternatives list.