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Can AMD Instinct MI250X run mistralai/Mistral-Small-Instruct-2409?

Runs Q4128GB VRAM availableRequires 11GB+

AMD Instinct MI250X meets the minimum VRAM requirement for Q4 inference of mistralai/Mistral-Small-Instruct-2409. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

What this means for you

AMD Instinct MI250X can run mistralai/Mistral-Small-Instruct-2409 with Q4 quantization. At approximately 284 tokens/second, you can expect Excellent speed - conversational response times under 1 second.

You have 117GB headroom, which is sufficient for system overhead and smooth operation.

Quantization breakdown

QuantizationVRAM neededVRAM availableEstimated speedVerdict
Q411GB128GB284.31 tok/s✅ Fits comfortably
Q823GB128GB188.20 tok/s✅ Fits comfortably
FP1646GB128GB99.14 tok/s✅ Fits comfortably

Suitable alternatives

AMD Instinct MI300X
192GB
445.24 tok/s
Price: —
NVIDIA H200 SXM 141GB
141GB
414.75 tok/s
Price: —
AMD Instinct MI300X
192GB
320.42 tok/s
Price: —
NVIDIA H100 SXM5 80GB
80GB
294.85 tok/s
Price: —
NVIDIA H200 SXM 141GB
141GB
269.62 tok/s
Price: —

More questions

AMD Instinct MI250X specs & pricingFull guide for mistralai/Mistral-Small-Instruct-2409mistralai/Mistral-Small-Instruct-2409 speed on AMD Instinct MI250Xmistralai/Mistral-Small-Instruct-2409 Q4 requirements