AMD Instinct MI250X meets the minimum VRAM requirement for Q4 inference of Qwen/Qwen3-Next-80B-A3B-Thinking-FP8. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.
AMD Instinct MI250X can run Qwen/Qwen3-Next-80B-A3B-Thinking-FP8 with Q4 quantization. At approximately 86 tokens/second, you can expect Good speed - acceptable for interactive use.
You have 89GB headroom, which is sufficient for system overhead and smooth operation.
| Quantization | VRAM needed | VRAM available | Estimated speed | Verdict |
|---|---|---|---|---|
| Q4 | 39GB | 128GB | 86.21 tok/s | ✅ Fits comfortably |
| Q8 | 78GB | 128GB | 67.82 tok/s | ✅ Fits comfortably |
| FP16 | 156GB | 128GB | 34.18 tok/s | ❌ Not recommended |