AMD Instinct MI250X meets the minimum VRAM requirement for Q4 inference of Qwen/Qwen2.5-Math-72B-Instruct. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.
AMD Instinct MI250X can run Qwen/Qwen2.5-Math-72B-Instruct with Q4 quantization. At approximately 105 tokens/second, you can expect Excellent speed - conversational response times under 1 second.
You have 92GB headroom, which is sufficient for system overhead and smooth operation.
| Quantization | VRAM needed | VRAM available | Estimated speed | Verdict |
|---|---|---|---|---|
| Q4 | 36GB | 128GB | 105.02 tok/s | ✅ Fits comfortably |
| Q8 | 71GB | 128GB | 65.71 tok/s | ✅ Fits comfortably |
| FP16 | 142GB | 128GB | 34.85 tok/s | ❌ Not recommended |