AMD Instinct MI250X meets the minimum VRAM requirement for Q4 inference of openai/gpt-oss-20b. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.
AMD Instinct MI250X can run openai/gpt-oss-20b with Q4 quantization. At approximately 282 tokens/second, you can expect Excellent speed - conversational response times under 1 second.
You have 118GB headroom, which is sufficient for system overhead and smooth operation.
| Quantization | VRAM needed | VRAM available | Estimated speed | Verdict |
|---|---|---|---|---|
| Q4 | 10GB | 128GB | 282.04 tok/s | ✅ Fits comfortably |
| Q8 | 20GB | 128GB | 181.04 tok/s | ✅ Fits comfortably |
| FP16 | 41GB | 128GB | 103.74 tok/s | ✅ Fits comfortably |