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GPUs for AI Models: Benchmarks & Specs

Can AMD Instinct MI250X run openai/gpt-oss-20b?

Runs Q4128GB VRAM availableRequires 10GB+

AMD Instinct MI250X meets the minimum VRAM requirement for Q4 inference of openai/gpt-oss-20b. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

Quantization breakdown

Quantization	VRAM needed	VRAM available	Estimated speed	Verdict
Q4	10GB	128GB	277.78 tok/s	✅ Fits comfortably
Q8	20GB	128GB	190.07 tok/s	✅ Fits comfortably
FP16	41GB	128GB	97.87 tok/s	✅ Fits comfortably

Suitable alternatives

AMD Instinct MI300X

192GB

459.29 tok/s

Price: —

NVIDIA H200 SXM 141GB

141GB

388.61 tok/s

Price: —

AMD Instinct MI300X

192GB

More questions

AMD Instinct MI250X specs & pricing Full guide for openai/gpt-oss-20b