Openai Gpt Oss 120B speed on AMD Instinct MI250X and quantization-level VRAM fit.
AMD Instinct MI250X meets the minimum VRAM requirement for Q4 inference of Openai Gpt Oss 120B. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.
AMD Instinct MI250X can run Openai Gpt Oss 120B with Q4 quantization. At approximately 96 tokens/second, you can expect Good speed - acceptable for interactive use.
You have 68GB headroom, which is sufficient for system overhead and smooth operation.
| Quantization | VRAM needed | VRAM available | Estimated speed | Verdict |
|---|---|---|---|---|
| Q4 | 60GB | 128GB | 95.51 tok/s | ✅ Fits comfortably |
| Q8 | 120GB | 128GB | 66.86 tok/s | ✅ Fits comfortably |
| FP16 | 240GB | 128GB | 36.29 tok/s | ❌ Not recommended |
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AMD Instinct MI250X can run Openai Gpt Oss 120B at Q4 with an estimated 96 tok/s.
Q4 inference is estimated to need about 60GB VRAM on this page, while AMD Instinct MI250X has 128GB available.
If you need more speed or context headroom, compare alternative GPUs below and check higher-tier VRAM options.