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GPUs for AI Models: Benchmarks & Specs

Can AMD Instinct MI250X run openai/gpt-oss-120b?

Runs Q4128GB VRAM availableRequires 59GB+

AMD Instinct MI250X meets the minimum VRAM requirement for Q4 inference of openai/gpt-oss-120b. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

Quantization breakdown

Quantization	VRAM needed	VRAM available	Estimated speed	Verdict
Q4	59GB	128GB	95.40 tok/s	✅ Fits comfortably
Q8	117GB	128GB	67.34 tok/s	✅ Fits comfortably
FP16	235GB	128GB	36.05 tok/s	❌ Not recommended

Suitable alternatives

AMD Instinct MI300X

192GB

157.81 tok/s

Price: —

NVIDIA H200 SXM 141GB

141GB

140.16 tok/s

Price: —

AMD Instinct MI300X

192GB

More questions

AMD Instinct MI250X specs & pricing Full guide for openai/gpt-oss-120b