AMD Instinct MI250X meets the minimum VRAM requirement for Q4 inference of lmstudio-community/DeepSeek-R1-0528-Qwen3-8B-MLX-4bit. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.
AMD Instinct MI250X can run lmstudio-community/DeepSeek-R1-0528-Qwen3-8B-MLX-4bit with Q4 quantization. At approximately 499 tokens/second, you can expect Excellent speed - conversational response times under 1 second.
You have 124GB headroom, which is sufficient for system overhead and smooth operation.
| Quantization | VRAM needed | VRAM available | Estimated speed | Verdict |
|---|---|---|---|---|
| Q4 | 4GB | 128GB | 498.93 tok/s | ✅ Fits comfortably |
| Q8 | 9GB | 128GB | 312.60 tok/s | ✅ Fits comfortably |
| FP16 | 17GB | 128GB | 194.73 tok/s | ✅ Fits comfortably |