RTX 5080 and AMD Instinct MI300X trade blows across speed and value.
Quick answer
AMD Instinct MI300X leads raw throughput, while RTX 5080 offers the stronger value profile for most buyers.
| Spec | RTX 5080 | AMD Instinct MI300X |
|---|---|---|
| VRAM | 16GB | 192GB |
| Cores | 10,752 | 19,456 |
| TDP | 360W | 750W |
| Architecture | Blackwell | CDNA 3 |
| Lowest price | — | — |
| Model | Quantization | RTX 5080 | AMD Instinct MI300X |
|---|---|---|---|
| TinyLlama/TinyLlama-1.1B-Chat-v1.0 | Q4 | 207.36 tok/s | 963.68 tok/s |
| ibm-granite/granite-3.3-2b-instruct | Q4 | 206.82 tok/s | 983.71 tok/s |
| nari-labs/Dia2-2B | Q4 | 206.77 tok/s | 919.40 tok/s |
| bigcode/starcoder2-3b | Q4 | 206.17 tok/s | 974.08 tok/s |
| tencent/HunyuanOCR | Q4 | 205.72 tok/s | 891.05 tok/s |
AMD Instinct MI300X wins pure speed in this comparison, while RTX 5080 is the better value option for price-to-performance.
Use the winner cards for a quick direction, then verify model compatibility with your target models and VRAM requirements before purchase.
Use the compatibility checker and model requirement pages to validate whether your target quantization and workload fit either GPU.