NVIDIA H100 SXM5 80GB and AMD Instinct MI300X trade blows across speed and value.
Quick answer
AMD Instinct MI300X leads raw throughput, while NVIDIA H100 SXM5 80GB offers the stronger value profile for most buyers.
| Spec | NVIDIA H100 SXM5 80GB | AMD Instinct MI300X |
|---|---|---|
| VRAM | 80GB | 192GB |
| Cores | 16,896 | 19,456 |
| TDP | 700W | 750W |
| Architecture | Hopper | CDNA 3 |
| Lowest price | — | — |
| Model | Quantization | NVIDIA H100 SXM5 80GB | AMD Instinct MI300X |
|---|---|---|---|
| google-bert/bert-base-uncased | Q4 | 651.74 tok/s | 973.98 tok/s |
| tencent/HunyuanOCR | Q4 | 646.70 tok/s | 891.05 tok/s |
| Qwen/Qwen3-ASR-1.7B | Q4 | 637.84 tok/s | 912.25 tok/s |
| unsloth/Llama-3.2-1B-Instruct | Q4 | 636.91 tok/s | 922.45 tok/s |
| meta-llama/Llama-3.2-3B-Instruct | Q4 | 633.16 tok/s | 885.01 tok/s |
AMD Instinct MI300X wins pure speed in this comparison, while NVIDIA H100 SXM5 80GB is the better value option for price-to-performance.
Use the winner cards for a quick direction, then verify model compatibility with your target models and VRAM requirements before purchase.
Use the compatibility checker and model requirement pages to validate whether your target quantization and workload fit either GPU.