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Can RTX 5080 run Qwen Qwen3 5 397B A17b?

Qwen Qwen3 5 397B A17b speed on RTX 5080 and quantization-level VRAM fit.

Q4 not recommended16GB VRAM availableRequires 199GB+

RTX 5080 does not meet the minimum VRAM requirement for Q4 inference of Qwen Qwen3 5 397B A17b. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

Buy options for RTX 5080Best GPU guidesCompare prebuilt systems
Short answer: RTX 5080 is not a comfortable Q4 fit for Qwen Qwen3 5 397B A17b (about 199GB needed).
Estimated speed
19 tok/s
VRAM needed
199GB
VRAM headroom
-183GB

What this means for you

RTX 5080 lacks sufficient VRAM for comfortable Qwen Qwen3 5 397B A17b operation with Q4 quantization.

Your 16GB GPU is 183GB short of the 199GB minimum.

Options: (1) Try Q2 or Q3 quantization for lower VRAM requirements, (2) Consider cloud GPU rental, (3) Upgrade to a GPU with at least 16GB VRAM.

Quantization breakdown

QuantizationVRAM neededVRAM availableEstimated speedVerdict
Q4199GB16GB18.97 tok/s❌ Not recommended
Q8397GB16GB13.28 tok/s❌ Not recommended
FP16794GB16GB7.21 tok/s❌ Not recommended

Suitable alternatives

No alternative GPUs with verified compatibility yet. Expand the compatibility import to surface more cards.

Compare purchase paths

Direct GPU buy options

Check current pricing links for RTX 5080 and similar cards.

Open RTX 5080 buy links →
Curated best GPU guides

Use workload-focused recommendations before committing to a purchase.

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Prebuilt AI systems

Compare complete systems if you want ready-to-run hardware.

Compare prebuilt systems →

Not ready to upgrade?

Your GPU doesn't meet the VRAM requirements. Run Qwen Qwen3 5 397B A17b on cloud GPU instantly.

Vast.aiFrom $0.20/hr · Pay as you goRent GPU →RunPodFrom $0.30/hr · Secure cloudRent GPU →Lambda LabsFrom $0.50/hr · Enterprise-gradeRent GPU →

More questions

RTX 5080 buy options & pricingFull guide for Qwen Qwen3 5 397B A17bBest GPU guides for this modelCompare prebuilt local AI systemsBrowse all model + GPU compatibility checksQwen Qwen3 5 397B A17b Q4 requirementsQwen Qwen3 5 397B A17b Q4_K_M requirements

Compatibility FAQ

Can RTX 5080 run Qwen Qwen3 5 397B A17b?

RTX 5080 is not a comfortable Q4 fit for Qwen Qwen3 5 397B A17b (about 199GB needed).

How much VRAM is needed for Qwen Qwen3 5 397B A17b on RTX 5080?

Q4 inference is estimated to need about 199GB VRAM on this page, while RTX 5080 has 16GB available.

What if RTX 5080 is not enough for Qwen Qwen3 5 397B A17b?

Try lower-bit quantization, choose a smaller model, or move to a higher-VRAM GPU from the alternatives list.