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Can AMD Instinct MI250X run swiss-ai/Apertus-8B-Instruct-2509?

Runs Q4128GB VRAM availableRequires 4GB+

AMD Instinct MI250X meets the minimum VRAM requirement for Q4 inference of swiss-ai/Apertus-8B-Instruct-2509. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

What this means for you

AMD Instinct MI250X can run swiss-ai/Apertus-8B-Instruct-2509 with Q4 quantization. At approximately 460 tokens/second, you can expect Excellent speed - conversational response times under 1 second.

You have 124GB headroom, which is sufficient for system overhead and smooth operation.

Quantization breakdown

QuantizationVRAM neededVRAM availableEstimated speedVerdict
Q44GB128GB459.82 tok/s✅ Fits comfortably
Q89GB128GB315.27 tok/s✅ Fits comfortably
FP1617GB128GB167.29 tok/s✅ Fits comfortably

Suitable alternatives

AMD Instinct MI300X
192GB
747.73 tok/s
Price: —
NVIDIA H200 SXM 141GB
141GB
647.30 tok/s
Price: —
AMD Instinct MI300X
192GB
586.94 tok/s
Price: —
NVIDIA H200 SXM 141GB
141GB
476.82 tok/s
Price: —
NVIDIA H100 SXM5 80GB
80GB
452.22 tok/s
Price: —

More questions

AMD Instinct MI250X specs & pricingFull guide for swiss-ai/Apertus-8B-Instruct-2509swiss-ai/Apertus-8B-Instruct-2509 speed on AMD Instinct MI250Xswiss-ai/Apertus-8B-Instruct-2509 Q4 requirements