Qwen Qwen3 Next 80B A3b Instruct FP8 speed on AMD Instinct MI250X and quantization-level VRAM fit.
AMD Instinct MI250X meets the minimum VRAM requirement for Q4 inference of Qwen Qwen3 Next 80B A3b Instruct FP8. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.
AMD Instinct MI250X can run Qwen Qwen3 Next 80B A3b Instruct FP8 with Q4 quantization. At approximately 96 tokens/second, you can expect Good speed - acceptable for interactive use.
You have 88GB headroom, which is sufficient for system overhead and smooth operation.
| Quantization | VRAM needed | VRAM available | Estimated speed | Verdict |
|---|---|---|---|---|
| Q4 | 40GB | 128GB | 95.51 tok/s | ✅ Fits comfortably |
| Q8 | 80GB | 128GB | 66.86 tok/s | ✅ Fits comfortably |
| FP16 | 160GB | 128GB | 36.29 tok/s | ❌ Not recommended |
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AMD Instinct MI250X can run Qwen Qwen3 Next 80B A3b Instruct FP8 at Q4 with an estimated 96 tok/s.
Q4 inference is estimated to need about 40GB VRAM on this page, while AMD Instinct MI250X has 128GB available.
If you need more speed or context headroom, compare alternative GPUs below and check higher-tier VRAM options.