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GPUs for AI Models: Benchmarks & Specs

Can AMD Instinct MI250X run Qwen/Qwen3-Next-80B-A3B-Instruct-FP8?

Runs Q4128GB VRAM availableRequires 39GB+

AMD Instinct MI250X meets the minimum VRAM requirement for Q4 inference of Qwen/Qwen3-Next-80B-A3B-Instruct-FP8. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

Quantization breakdown

Quantization	VRAM needed	VRAM available	Estimated speed	Verdict
Q4	39GB	128GB	96.27 tok/s	✅ Fits comfortably
Q8	78GB	128GB	64.93 tok/s	✅ Fits comfortably
FP16	156GB	128GB	32.80 tok/s	❌ Not recommended

Suitable alternatives

AMD Instinct MI300X

192GB

158.66 tok/s

Price: —

NVIDIA H200 SXM 141GB

141GB

142.40 tok/s

Price: —

AMD Instinct MI300X

192GB

More questions

AMD Instinct MI250X specs & pricing Full guide for Qwen/Qwen3-Next-80B-A3B-Instruct-FP8