AMD Instinct MI250X meets the minimum VRAM requirement for Q4 inference of Qwen/Qwen3-4B-Base. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.
AMD Instinct MI250X can run Qwen/Qwen3-4B-Base with Q4 quantization. At approximately 439 tokens/second, you can expect Excellent speed - conversational response times under 1 second.
You have 126GB headroom, which is sufficient for system overhead and smooth operation.
| Quantization | VRAM needed | VRAM available | Estimated speed | Verdict |
|---|---|---|---|---|
| Q4 | 2GB | 128GB | 439.30 tok/s | ✅ Fits comfortably |
| Q8 | 4GB | 128GB | 341.28 tok/s | ✅ Fits comfortably |
| FP16 | 9GB | 128GB | 195.65 tok/s | ✅ Fits comfortably |