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Can AMD Instinct MI250X run Nousresearch Hermes 3 Llama 3 1 70B?

Nousresearch Hermes 3 Llama 3 1 70B speed on AMD Instinct MI250X and quantization-level VRAM fit.

Runs Q4128GB VRAM availableRequires 35GB+

AMD Instinct MI250X meets the minimum VRAM requirement for Q4 inference of Nousresearch Hermes 3 Llama 3 1 70B. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

Buy options for AMD Instinct MI250XBest GPU guidesCompare prebuilt systems
Short answer: AMD Instinct MI250X can run Nousresearch Hermes 3 Llama 3 1 70B at Q4 with an estimated 167 tok/s.
Estimated speed
167 tok/s
VRAM needed
35GB
VRAM headroom
+93GB

What this means for you

AMD Instinct MI250X can run Nousresearch Hermes 3 Llama 3 1 70B with Q4 quantization. At approximately 167 tokens/second, you can expect Excellent speed - conversational response times under 1 second.

You have 93GB headroom, which is sufficient for system overhead and smooth operation.

Quantization breakdown

QuantizationVRAM neededVRAM availableEstimated speedVerdict
Q435GB128GB167.14 tok/s✅ Fits comfortably
Q870GB128GB117.00 tok/s✅ Fits comfortably
FP16140GB128GB63.51 tok/s❌ Not recommended

Suitable alternatives

AMD Instinct MI300X
192GB
267.14 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Nousresearch Hermes 3 Llama 3 1 70B on AMD Instinct MI300X
NVIDIA H200 SXM 141GB
141GB
241.24 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Nousresearch Hermes 3 Llama 3 1 70B on NVIDIA H200 SXM 141GB
NVIDIA H100 SXM5 80GB
80GB
173.27 tok/s
Price: —
Fit note: higher estimated speed than the baseline option.
Check Nousresearch Hermes 3 Llama 3 1 70B on NVIDIA H100 SXM5 80GB
NVIDIA H100 PCIe 80GB
80GB
109.99 tok/s
Price: —
Fit note: compare VRAM and speed with your target workload before buying.
Check Nousresearch Hermes 3 Llama 3 1 70B on NVIDIA H100 PCIe 80GB
NVIDIA A100 80GB SXM4
80GB
102.22 tok/s
Price: —
Fit note: compare VRAM and speed with your target workload before buying.
Check Nousresearch Hermes 3 Llama 3 1 70B on NVIDIA A100 80GB SXM4

GPU buying guides

Need a GPU with 35GB+ VRAM? These guides match your requirements.

Best GPU for Llama 3
GPU picks tuned for Llama 3 inference from 8B to 70B.
Read guide →
Best GPU for 70B Models
Hardware for running 70B-class models with realistic tradeoffs.
Read guide →
Best GPU for LLMs
Optimized for running large language models locally.
Read guide →

Compare purchase paths

Direct GPU buy options

Check current pricing links for AMD Instinct MI250X and similar cards.

Open AMD Instinct MI250X buy links →
Curated best GPU guides

Use workload-focused recommendations before committing to a purchase.

Browse best GPU guides →
Prebuilt AI systems

Compare complete systems if you want ready-to-run hardware.

Compare prebuilt systems →

Try before you buy

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Vast.aiFrom $0.20/hr · Pay as you goRent GPU →RunPodFrom $0.30/hr · Secure cloudRent GPU →Lambda LabsFrom $0.50/hr · Enterprise-gradeRent GPU →

More questions

AMD Instinct MI250X buy options & pricingFull guide for Nousresearch Hermes 3 Llama 3 1 70BBest GPU guides for this modelCompare prebuilt local AI systemsBrowse all model + GPU compatibility checksNousresearch Hermes 3 Llama 3 1 70B Q4 requirementsNousresearch Hermes 3 Llama 3 1 70B Q4_K_M requirementsCan AMD Instinct MI300X run Nousresearch Hermes 3 Llama 3 1 70B?Can NVIDIA H200 SXM 141GB run Nousresearch Hermes 3 Llama 3 1 70B?Can NVIDIA H100 SXM5 80GB run Nousresearch Hermes 3 Llama 3 1 70B?

Compatibility FAQ

Can AMD Instinct MI250X run Nousresearch Hermes 3 Llama 3 1 70B?

AMD Instinct MI250X can run Nousresearch Hermes 3 Llama 3 1 70B at Q4 with an estimated 167 tok/s.

How much VRAM is needed for Nousresearch Hermes 3 Llama 3 1 70B on AMD Instinct MI250X?

Q4 inference is estimated to need about 35GB VRAM on this page, while AMD Instinct MI250X has 128GB available.

What if AMD Instinct MI250X is not enough for Nousresearch Hermes 3 Llama 3 1 70B?

If you need more speed or context headroom, compare alternative GPUs below and check higher-tier VRAM options.