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Can AMD Instinct MI210 run Mistralai Mistral Large 3 675B Instruct 2512?

Mistralai Mistral Large 3 675B Instruct 2512 speed on AMD Instinct MI210 and quantization-level VRAM fit.

Q4 not recommended64GB VRAM availableRequires 338GB+

AMD Instinct MI210 does not meet the minimum VRAM requirement for Q4 inference of Mistralai Mistral Large 3 675B Instruct 2512. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

Buy options for AMD Instinct MI210Best GPU guidesCompare prebuilt systems
Short answer: AMD Instinct MI210 is not a comfortable Q4 fit for Mistralai Mistral Large 3 675B Instruct 2512 (about 338GB needed).
Estimated speed
29 tok/s
VRAM needed
338GB
VRAM headroom
-274GB

What this means for you

AMD Instinct MI210 lacks sufficient VRAM for comfortable Mistralai Mistral Large 3 675B Instruct 2512 operation with Q4 quantization.

Your 64GB GPU is 274GB short of the 338GB minimum.

Options: (1) Try Q2 or Q3 quantization for lower VRAM requirements, (2) Consider cloud GPU rental, (3) Upgrade to a GPU with at least 16GB VRAM.

Quantization breakdown

QuantizationVRAM neededVRAM availableEstimated speedVerdict
Q4338GB64GB28.52 tok/s❌ Not recommended
Q8675GB64GB19.96 tok/s❌ Not recommended
FP161350GB64GB10.84 tok/s❌ Not recommended

Suitable alternatives

No alternative GPUs with verified compatibility yet. Expand the compatibility import to surface more cards.

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Direct GPU buy options

Check current pricing links for AMD Instinct MI210 and similar cards.

Open AMD Instinct MI210 buy links →
Curated best GPU guides

Use workload-focused recommendations before committing to a purchase.

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Prebuilt AI systems

Compare complete systems if you want ready-to-run hardware.

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Not ready to upgrade?

Your GPU doesn't meet the VRAM requirements. Run Mistralai Mistral Large 3 675B Instruct 2512 on cloud GPU instantly.

Vast.aiFrom $0.20/hr · Pay as you goRent GPU →RunPodFrom $0.30/hr · Secure cloudRent GPU →Lambda LabsFrom $0.50/hr · Enterprise-gradeRent GPU →

More questions

AMD Instinct MI210 buy options & pricingFull guide for Mistralai Mistral Large 3 675B Instruct 2512Best GPU guides for this modelCompare prebuilt local AI systemsBrowse all model + GPU compatibility checksMistralai Mistral Large 3 675B Instruct 2512 Q4 requirementsMistralai Mistral Large 3 675B Instruct 2512 Q4_K_M requirements

Compatibility FAQ

Can AMD Instinct MI210 run Mistralai Mistral Large 3 675B Instruct 2512?

AMD Instinct MI210 is not a comfortable Q4 fit for Mistralai Mistral Large 3 675B Instruct 2512 (about 338GB needed).

How much VRAM is needed for Mistralai Mistral Large 3 675B Instruct 2512 on AMD Instinct MI210?

Q4 inference is estimated to need about 338GB VRAM on this page, while AMD Instinct MI210 has 64GB available.

What if AMD Instinct MI210 is not enough for Mistralai Mistral Large 3 675B Instruct 2512?

Try lower-bit quantization, choose a smaller model, or move to a higher-VRAM GPU from the alternatives list.